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首页-小分子抑制剂&激动剂-Others-Mitochondrial Permeability Transition Pore (mPTP)-GNX-865
GNX-865

Chemical Structure : GNX-865

CAS No.: 1223568-82-8

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GNX-865 (GNX865)

货号: PC-62131Not For Human Use, Lab Use Only.

GNX-865 is a potent mitochondrial permeability transition pore (mPTP) inhibitor with EC50 of 105 uM (mitochondrial swelling).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    GNX-865 is a potent mitochondrial permeability transition pore (mPTP) inhibitor with EC50 of 105 uM (mitochondrial swelling).
    GNX-865 attenuates opening of the mPTP and limits reperfusion injury in a rabbit model of acute myocardial infarction.

    物理化学性质&存储条件

    分子量 303.742
    分子式 C16H14ClNO3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-N-(3-Chloro-phenyl)-3-(3-hydroxy-4-methoxy-phenyl)-acrylamide

    参考文献

    1. Fancelli D, et al. J Med Chem. 2014 Jun 26;57(12):5333-47.

    2. Roy S, et al. ChemMedChem. 2015 Oct;10(10):1655-71.

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