GNS-3595 | ROCK2 inhibitor | Probechem Biochemicals

Chemical Structure : GNS-3595

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GNS-3595 (GNS3595)

货号: PC-22511Not For Human Use, Lab Use Only.

GNS-3595 is a potent and selective ROCK2 inhibitor with IC50 of 5.7 nM, 80-fold selectivity over ROCK1 at 1mM ATP.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

GNS-3595 is a potent and selective ROCK2 inhibitor with IC50 of 5.7 nM, 80-fold selectivity over ROCK1 at 1mM ATP.
GNS-3595 inhibits pMLC activity in various cellines, and significantly down-regulates pro-fibrotic proteins such as co lagen, fibronectin, αSMA and CTGF in IPF cells, and suppresss TGF-β-induced FMT in NHLF cells.
GNS-3595 exhibits excellent oral bioavailability and drug-like properties.
GNS-3595 suppresses pulmonary lung fibrosis in a bleomycin-induced in vivo mouse model, stabilizes body weight loss and prevents fibrosis-induced lung weight gain.
GNS-3595 at oral dose of 0.1, 0.3 or 1 mg/kg once daily, showed a significant reduction in Ashcroft scores, colagen, and αSMA, in a dose-dependent manner.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Soyoung Hwang, et al. Am J Respir Cell Mol Biol. 2024 Jun 11. doi: 10.1165/rcmb.2023-0401OC.

GNS-3595 (GNS3595)

生物&药学活性

物理化学性质&存储条件

参考文献

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GNS-3595 (GNS3595)

生物&药学活性

物理化学性质&存储条件

参考文献

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