GNS-1481 |CAS:1903008-81-0 Probechem Biochemicals

Chemical Structure : GNS-1481

加入收藏

GNS-1481 (GNS1481;GNS 1481)

货号: PC-60919Not For Human Use, Lab Use Only.

A novel potent, irreversible, T790M mutant-selective inhibitor of mutant EGFR with IC50 of 6.2, 3.4 and 4.2 nM for L858R-T790M, T790M and Del19-T790M, respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

GNS-1481 is a potent, irreversible, T790M mutant-selective inhibitor of mutant EGFR with IC50 of 6.2, 3.4 and 4.2 nM for L858R-T790M, T790M and Del19-T790M, respectively.
GNS-1481 displays >5-fold selectivity over wild type EGFR (IC50=26.5 nM) and L858R mutant (IC50=25.8 nM).
GNS-1481 demonstrates effectivity in multiple mouse xenograft models of human lung adenocarcinoma (T790M-positive or -negative), exhibiting less activity against wild-type EGFR than existing approved EGFR kinase inhibitors (including osimertinib).
GNS-1481 also shows superior potency against intracranial metastasis of EGFR-mutant lung adenocarcinoma.

物理化学性质&存储条件

分子量	518.622
分子式	C27H34N8O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-((4-(3-cyclopropyl-4-((dimethylamino)methyl)-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide

参考文献

1. Rho JK, et al. Cancer Res. 2017 Mar 1;77(5):1200-1211.

GNS-1481 (GNS1481;GNS 1481)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

GNS-1481 (GNS1481;GNS 1481)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.