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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-NAMPT-GNI-50
GNI-50

Chemical Structure : GNI-50

CAS No.: 1363154-45-3

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GNI-50 (GNI50, NAMPT inhibitor)

货号: PC-73040Not For Human Use, Lab Use Only.

GNI-50 is a potent, selective Nampt inhibitor with enzyme IC50 of 7 nM, A2780 cellular IC50 of 32 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    GNI-50 is a potent, selective Nampt inhibitor with enzyme IC50 of 7 nM, A2780 cellular IC50 of 32 nM.
    GNI-50 showed excellent in vivo antitumor efficacy when dosed orally in an A2780 ovarian tumor xenograft model (TGI of 97% was observed on day 17).

    物理化学性质&存储条件

    分子量 402.469
    分子式 C19H22N4O4S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(4-(((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)sulfonyl)phenyl)-3-(pyridin-3-ylmethyl)urea

    参考文献

    1. Zheng X, et al. J Med Chem. 2013 Jun 27;56(12):4921-37.

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