欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Tyrosine Kinase-DYRK-GNF4877
GNF4877

Chemical Structure : GNF4877

CAS No.: 2041073-22-5

加入收藏

GNF4877 (GNF-4877)

货号: PC-22435Not For Human Use, Lab Use Only.

GNF4877 is a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) with IC50 of 6 nM and 16 nM, respectively, has a synergistic effect enhancing β-cell proliferation.

规格 价格 库存 数量
5 mg ￥2880 In stock
10 mg ￥4580 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GNF4877 is a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) with IC50 of 6 nM and 16 nM, respectively, has a synergistic effect enhancing β-cell proliferation.
GNF4877 induces primary human β-cell proliferation in vitro and in vivo. induced β-cell proliferation.
GNF4877 increases β-cell mass and insulin content and improves glycemic control in diabetic mice.

物理化学性质&存储条件

分子量 494.53
分子式 C25H27FN6O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-1-(3-(3-Amino-6-(2-fluoro-5-isopropoxyphenyl)pyrazine-2-carboxamido)pyridin-4-yl)piperidine-3-carboxylic acid

参考文献

1. Liu YA, et al. ChemMedChem. 2020 Aug 19;15(16):1562-1570.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: