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首页-小分子抑制剂&激动剂-Others-Other Targets-GNF362
GNF362

Chemical Structure : GNF362

CAS No.: 1003019-41-7

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GNF362 (GNF-362, GNF 362)

货号: PC-73103Not For Human Use, Lab Use Only.

GNF362 (GNF-362) is a highly potent, selective inhibitor of inositol 1,4,5-trisphosphate 3-kinase B (ITPKB) with IC50 of 9 nM.

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5 mg ￥2880 In stock
10 mg ￥4580 In stock
25 mg ￥7280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GNF362 (GNF-362) is a highly potent, selective inhibitor of inositol 1,4,5-trisphosphate 3-kinase B (ITPKB) with IC50 of 9 nM.
GNF362 also inhibits Itpka (expressed in the brain, IC50=20 nM) and Itpkc (IC50=19 nM), GNF362 has no activity against a panel of >150 proteins or lipid kinases.
GNF362 ameliorated acute GVHD without impairing GVL against 2 acute myeloid leukemia lines (MLL-AF9-eGFP and C1498-luciferase).
GNF362 more selectively deleted alloreactive T cells without eliminating GVL compared with FK506.
GNF362 attenuated aGVHD lethality in vivo administration.
GNF362 reversed established cGVHD BO and inhibited lung macrophage infiltration, but did not alter GC reactions in both BO and scleroderma models.
GNF362 reversed skin disease in mice with cGVHD and scleroderma.

物理化学性质&存储条件

分子量 426.44
分子式 C22H21F3N6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[4-[[(3R)-3-methyl-4-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinyl]methyl]-1H-pyrazol-3-yl]-benzonitrile

参考文献

1. Thangavelu G, et al. Blood. 2020 Jan 2;135(1):28-40.

2. Miller AT, et al. PLoS One. 2015; 10(6):e0131071.

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