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首页-小分子抑制剂&激动剂-Tyrosine Kinase-DYRK-GNF2133
GNF2133

Chemical Structure : GNF2133

CAS No.: 2561414-56-8

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GNF2133 (GNF-2133)

货号: PC-72351Not For Human Use, Lab Use Only.

GNF2133 (GNF-2133) is a potent and selective DYRK1A inhibitor with IC50 of 6 nM, without inhibitory effect on GSK3β.

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5 mg ￥2980 In stock
10 mg ￥4580 In stock
25 mg ￥7580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GNF2133 (GNF-2133) is a potent and selective DYRK1A inhibitor with IC50 of 6 nM, without inhibitory effect on GSK3β.
In vitro, GNF2133 is able to proliferate both rodent and human β-cells.
In vivo, GNF2133 demonstrated significant dose-dependent glucose disposal capacity and insulin secretion in response to glucose-potentiated arginine-induced insulin secretion (GPAIS) challenge in rat insulin promoter and diphtheria toxin A (RIP-DTA) mice.

物理化学性质&存储条件

分子量 434.544
分子式 C24H30N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Piperazinecarboxamide, 4-ethyl-N-[4-[1-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-2-pyridinyl]-

参考文献

1. Yahu A Liu, et al. J Med Chem. 2020 Mar 26;63(6):2958-2973.

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