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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Bcr-Abl-GNF-7
GNF-7

Chemical Structure : GNF-7

CAS No.: 839706-07-9

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GNF-7 (GNF 7, GNF7)

货号: PC-42749Not For Human Use, Lab Use Only.

GNF-7 is a potent and selective type-II kinase inhibitor of Bcr-Abl, inhibits wt Bcr-Abl/T315I Bcr-Abl (IC50< 5 nM).

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GNF-7 is a potent and selective type-II kinase inhibitor of Bcr-Abl, inhibits wt Bcr-Abl/T315I Bcr-Abl (IC50< 5 nM).
GNF-7 inhibits Bcr-Abl mutants such as G250E, Q252H, Y253H, E255K, E255V, F317L, and M351T in biochemical and cellular assays.
GNF-7 displays in vivo efficacy against T315I-Bcr-Abl in xenograft mouse model.

物理化学性质&存储条件

分子量 547.5311
分子式 C28H24F3N7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 33 mg/mL
Chemical Name/SMILES

Benzamide, N-[3-[1,4-dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)-

参考文献

1. Choi HG, et al. J Med Chem. 2010 Aug 12;53(15):5439-48.

2. Nonami A, et al. Blood. 2015 May 14;125(20):3133-43.

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