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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Aryl hydrocarbon Receptor (AhR)-GNF-351
GNF-351

Chemical Structure : GNF-351

CAS No.: 1227634-69-6

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GNF-351 (GNF 351;GNF351)

货号: PC-60390Not For Human Use, Lab Use Only.

GNF-351 is a potent, pure aryl hydrocarbon receptor (AHR) antagonist (IC50=62 nM) devoid of partial agonist potential.

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5 mg ￥880 In stock
10 mg ￥1380 In stock
25 mg ￥2280 In stock
50 mg ￥3680 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GNF-351 is a potent, pure aryl hydrocarbon receptor (AHR) antagonist (IC50=62 nM) devoid of partial agonist potential.
GNF-351 antagonizes agonist and SAhRM-mediated suppression of SAA1, inhibits both DRE-dependent and -independent activity.
GNF-351 decreases migration and invasion of HNSCC cells and prevents benzo[a]pyrene-mediated induction of the chemotherapy efflux protein ABCG2.

物理化学性质&存储条件

分子量 411.5
分子式 C24H25N7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-(3H-Indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)-7H-purin-6-amine

参考文献

1. Smith KJ, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):318-27.

2. Fang ZZ, et al. Br J Pharmacol. 2014 Apr;171(7):1735-46.

3. DiNatale BC, et al. Mol Cancer Res. 2012 Oct;10(10):1369-79.

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