GNE-886 |CAS:2101957-05-3 Probechem Biochemicals

Chemical Structure : GNE-886

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GNE-886 (GNE886)

货号: PC-62550Not For Human Use, Lab Use Only.

GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM.

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生物&药学活性

GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM.
GNE-886 shows a wide selectivity over the 40 bromodomains, >100-fold selectivity over BRD9, BRD7, TAF1(2), and BRD4(1).
GNE-886 has a highly favorable measured kinetic solubility of 122 uM and is an appropriate in vitro tool compound for the CECR2 bromodomain.

物理化学性质&存储条件

分子量	498.587
分子式	C28H30N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-allyl-N-(1-(6-(3-methoxyphenyl)pyrimidin-4-yl)piperidin-4-yl)-N-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-carboxamide

参考文献

1. Crawford TD, et al. ACS Med Chem Lett. 2017 Jun 1;8(7):737-741.

GNE-886 (GNE886)

生物&药学活性

物理化学性质&存储条件

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GNE-886 (GNE886)

生物&药学活性

物理化学性质&存储条件

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