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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MAP4K-GNE-6893
GNE-6893

Chemical Structure : GNE-6893

CAS No.: 2415374-98-8

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GNE-6893 (GNE6893)

货号: PC-23064Not For Human Use, Lab Use Only.

GNE-6893 is a potent, selective and orally active inhibitor of HPK1 (hematopoietic progenitor kinase 1) with Ki of <0.019 nM, potently inhibits phosphorylation of SLP76 with IC50 of 44 nM in Jurkat cell assay.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GNE-6893 is a potent, selective and orally active inhibitor of HPK1 (hematopoietic progenitor kinase 1) with Ki of <0.019 nM, potently inhibits phosphorylation of SLP76 with IC50 of 44 nM in Jurkat cell assay.
GNE-6893 potently elevates IL2 secretion with EC50 of 6.4 nM in primary human T-cells stimulated with anti-CD3 and anti-CD28.
GNE-6893 exhibits high kinase selectivity and robust activation of T-cell signaling, as well as favorable pharmacokinetic and in vitro safety profiles.

物理化学性质&存储条件

分子量 453.47
分子式 C23H24FN5O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3R,4S)-4-methyltetrahydrofuran-3-yl (8-amino-7-fluoro-6-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)isoquinolin-3-yl)carbamate

参考文献

1. Tellis JC, et al. ACS Med Chem Lett. 2024 Sep 3;15(9):1606-1614.

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