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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-GNE-6776
GNE-6776

Chemical Structure : GNE-6776

CAS No.: 2009273-71-4

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GNE-6776 (GNE6776, GNE 6776)

货号: PC-60089Not For Human Use, Lab Use Only.

GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM.

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5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM.
GNE-6776 dislpalys selectivity over USP47 and USP5 (>200 uM).
GNE-6776 promotes endogenous MDM2 ubiquitination, stabilized p53 and upregulated p21, induces tumour cell death and enhances cytotoxicity with chemotherapeutic agents.
GNE-6776 promotes on-target pathway modulation in human xenografts.

物理化学性质&存储条件

分子量 348.406
分子式 C20H20N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-[6-Amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridyl]-N-methyl-pyridine-2carboxamide

参考文献

1. Kategaya L, et al. Nature. 2017 Oct 26;550(7677):534-538.

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