GNE-618 | NAMPT inhibitor | Probechem Biochemicals

Chemical Structure : GNE-618

CAS No.: 1362151-42-5

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GNE-618 (GNE618)

货号: PC-38787Not For Human Use, Lab Use Only.

GNE-618 is a potent, selective NAMPT inhibitor with IC50 of 6 nM, depletes NAD and induces cell death in vitro and in vivo.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
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100 mg		Get quote

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生物&药学活性

GNE-618 is a potent, selective NAMPT inhibitor with IC50 of 6 nM, depletes NAD and induces cell death in vitro and in vivo.
GNE-618 reduced levels of NAD with an 50% minimal response (EC50) of 2.6 nM in the NSCLC cell line Calu-6, reduced cellular proliferation of Calu-6 cells with IC50 of 13. 6 nM.
NAMPT, but not NAPRT1, mRNA and protein levels inversely correlate with sensitivity to GNE-618 across a panel of 53 non-small cell lung carcinoma cell lines.
GNE-618 inhibits in vivo tumor growth in an A549 non-small cell lung carcinoma (NSCLC) model.

物理化学性质&存储条件

分子量	460.43
分子式	C21H15F3N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[[4-[[3-(Trifluoromethyl)phenyl]sulfonyl]phenyl]methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

参考文献

1. O'Brien T, et al. Neoplasia. 2013 Dec;15(12):1314-29.

2. Xiao Y, et al. Neoplasia. 2013 Oct;15(10):1151-60.

3. Zheng X, et al. J Med Chem 2013;56:6413–33.

GNE-618 (GNE618)

生物&药学活性

物理化学性质&存储条件

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GNE-618 (GNE618)

生物&药学活性

物理化学性质&存储条件

参考文献

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