GNE-5729 | GluN2A PAM | Probechem Biochemicals

Chemical Structure : GNE-5729

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货号: PC-20370Not For Human Use, Lab Use Only.

GNE-5729 (GNE5729) is a potent, brain penetrant GluN2A-selective NMDAR positive allosteric modulator with EC50 of 37 nM.

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GNE-5729 (GNE5729) is a potent, brain penetrant GluN2A-selective NMDAR positive allosteric modulator with EC50 of 37 nM.

分子量	428.20
分子式	C17H10Cl2F3N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2R)-2-(7-chloro-2-((5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-6-yl)cyclopropane-1-carbonitrile

1. Elisia Villemure, et al. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89.