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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MAP4K-GNE-495
GNE-495

Chemical Structure : GNE-495

CAS No.: 1449277-10-4

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GNE-495 (GNE 495;GNE495)

货号: PC-42105Not For Human Use, Lab Use Only.

GNE-495 (GNE495) is a potent and highly selective, cell permeable MAP4K4 inhibitor with IC50 of 3.7 nM.

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5 mg ￥980 In stock
10 mg ￥1580 In stock
25 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GNE-495 (GNE495) is a potent and highly selective, cell permeable MAP4K4 inhibitor with IC50 of 3.7 nM.
GNE-495 exhibits adequate potency preventing migration of HUVEC cells in vitro (IC50=57 nM).
GNE-495 has good PK and demonstrates in vivo efficacy in a retinal angiogenesis model .

物理化学性质&存储条件

分子量 405.4249
分子式 C22H20FN5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 10 mg/mL
Chemical Name/SMILES

1,7-Naphthyridine-5-carboxamide, 8-amino-N-[1-(cyclopropylcarbonyl)-3-azetidinyl]-2-(3-fluorophenyl)-

参考文献

1. Ndubaku CO, et al. ACS Med Chem Lett. 2015 Jun 29;6(8):913-8.

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