GNE-490 |CAS:1033739-92-2 Probechem Biochemicals

Chemical Structure : GNE-490

CAS No.: 1033739-92-2

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GNE-490 (GNE490)

货号: PC-63013Not For Human Use, Lab Use Only.

GNE-490 is a potent, selective, orally available class I PI3K inhibitor with IC50 of 3.5/25/5.2/15 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ.

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5 mg	￥2780	In stock
10 mg	￥4580	In stock
25 mg	￥7580	In stock
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100 mg		Get quote

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生物&药学活性

GNE-490 is a potent, selective, orally available class I PI3K inhibitor with IC50 of 3.5/25/5.2/15 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ。
GNE-490 shows >200-fold selectivity over mTOR (IC50=740 nM)。
GNE-490 has good PK profiles, and are efficacious in xenograft models.

物理化学性质&存储条件

分子量	386.474
分子式	C18H22N6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-Amino-4-methyl-5-pyrimidinyl)-α,α-dimethyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidine-6-methanol

参考文献

1. Sutherlin DP, et al. J Med Chem. 2010 Feb 11;53(3):1086-97.

2. Sampath D, et al. Neoplasia. 2013 Jul;15(7):694-711.

GNE-490 (GNE490)

生物&药学活性

物理化学性质&存储条件

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GNE-490 (GNE490)

生物&药学活性

物理化学性质&存储条件

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