GNE-293 |CAS:1354955-67-1 Probechem Biochemicals

Chemical Structure : GNE-293

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GNE-293 (GNE293)

货号: PC-62886Not For Human Use, Lab Use Only.

GNE-293 is a potent and selective PI3Kδ inhibitor with Ki of 0.47 nM, displays 256, 420, 219-fold selectivity over PI3Kα, PI3Kβ, PI3Kγ, respectively.

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生物&药学活性

GNE-293 is a potent and selective PI3Kδ inhibitor with Ki of 0.47 nM, displays 256, 420, 219-fold selectivity over PI3Kα, PI3Kβ, PI3Kγ, respectively。
GNE-293 exhibits excellent potency in human whole blood (HWB) assay (CD69 HWB IC50=4.38 nM)。
GNE-293 possesses favorable pharmacokinetic properties and orally bioavailable.

物理化学性质&存储条件

分子量	580.708
分子式	C28H36N8O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-((2-(2-isopropyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purin-8-yl)oxy)azetidin-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide

参考文献

1. Safina BS, et al. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4953-9.

GNE-293 (GNE293)

生物&药学活性

物理化学性质&存储条件

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GNE-293 (GNE293)

生物&药学活性

物理化学性质&存储条件

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