GNE-272 |Cas:1936428-93-1 Buy GNE-272 from ProbeChem, Global Biochemicals Supplier

Chemical Structure : GNE-272

CAS No.: 1936428-93-1

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GNE-272 (GNE 272;GNE272)

货号: PC-60305Not For Human Use, Lab Use Only.

GNE-272 (GNE272) potent and selective the bromodomains of CBP/EP300 inhibitor with IC50 of 0.02 and 0.03 uM for CBP and EP300, respectively.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GNE-272 (GNE272) potent and selective the bromodomains of CBP/EP300 inhibitor with IC50 of 0.02 and 0.03 uM for CBP and EP300, respectively.
GNE-272 displays high selectivity over BRD4 (1) and other BRDs (>10 uM).
GNE-272 shows antiproliferative effect in hematologic cancer cell lines and modulates MYC expression in vivo.
GNE-272 exhibits excellent in vivo PK and antitumor activity in an AML tumor model.

物理化学性质&存储条件

分子量	424.48
分子式	C22H25FN6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(3-((2-Fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)ethanone

参考文献

1. Crawford TD, et al. J Med Chem. 2016 Dec 8;59(23):10549-10563.

GNE-272 (GNE 272;GNE272)

生物&药学活性

物理化学性质&存储条件

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GNE-272 (GNE 272;GNE272)

生物&药学活性

物理化学性质&存储条件

参考文献

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