GNE-220 hydrochloride | MAP4K4 inhibitor | Probechem Biochemicals

Chemical Structure : GNE-220 hydrochloride

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GNE-220 hydrochloride (GNE220, GNE 220)

货号: PC-28613Not For Human Use, Lab Use Only.

GNE-220 hydrochloride is a potent and selective inhibitor of MAP4K4 with IC50 of 7 nM, also inhibits MINK (MAP4K6), DMPK and KHS1 (MAP4K5) with IC50 of 9 nM, 476 nM and 1,110 nM.

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生物&药学活性

GNE-220 hydrochloride is a potent and selective inhibitor of MAP4K4 with IC50 of 7 nM, also inhibits MINK (MAP4K6), DMPK and KHS1 (MAP4K5) with IC50 of 9 nM, 476 nM and 1,110 nM.
GNE-220 alters HUVEC sprout morphology, shifts the distribution of subcellular protrusion and increases total protrusions。
GNE-220 dose-dependently increases the number of β1-integrin in long focal adhesions.

物理化学性质&存储条件

分子量	475.00
分子式	C25H27ClN8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Methyl-8-[4-(4-methyl-1-piperazinyl)phenyl]-2-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[3',2':4,5]pyrrolo[3,2-d]pyrimidine hydrochloride

参考文献

1. Vitorino P, et al. Nature. 2015 Mar 26;519(7544):425-30.

2. Gao X, et al. Cell Biosci. 2016 Oct 28;6:56. eCollection 2016.

GNE-220 hydrochloride (GNE220, GNE 220)

生物&药学活性

物理化学性质&存储条件

参考文献

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GNE-220 hydrochloride (GNE220, GNE 220)

生物&药学活性

物理化学性质&存储条件

参考文献

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