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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MAP4K-GNE-1858
GNE-1858

Chemical Structure : GNE-1858

CAS No.: 2680616-96-8

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GNE-1858 (GNE1858)

货号: PC-72304Not For Human Use, Lab Use Only.

GNE-1858 (GNE1858) is a potent, selective, ATP-competitive inhibitor of HPK1 (MAP4K1) with IC50 of 1.9 nM in the SLP76 phosphorylation assay.

规格 价格 库存 数量
2 mg ￥1980 In stock
5 mg ￥3280 In stock
10 mg ￥5280 In stock
25 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GNE-1858 (GNE1858) is a potent, selective, ATP-competitive inhibitor of HPK1 (MAP4K1) with IC50 of 1.9 nM in the SLP76 phosphorylation assay.
GNE-1858 potently inhibits all three HPK1 kinase domain variants under investigation in a dose-dependent manner (IC50=4.5 nM against the residual kinase activity of HPK1-SA).

物理化学性质&存储条件

分子量 428.492
分子式 C21H26F2N8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Pyrazolo[4,3-c]pyridin-6-amine, N-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]-1-(1-methylethyl)-

参考文献

1. Wu P, et al. Structure. 2019 Jan 2;27(1):125-133.e4.

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