GNE-140 racemate |CAS:1802977-61-2 Probechem Biochemicals

Chemical Structure : GNE-140 racemate

CAS No.: 1802977-61-2

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GNE-140 racemate (GNE 140 racemate;GNE140 racemate)

货号: PC-42245Not For Human Use, Lab Use Only.

GNE-140 racemate is the racemate of GNE-140, a novel potent, selective lactate dehydrogenase (LDH) inhibitor with IC50 of 3, 5, and 5 nM for LDHA, LDHB, and LDHC, respectively.

规格	价格	库存
5 mg	￥1480	In stock
25 mg	￥3280	In stock
100 mg	￥8480	In stock
500 mg		Get quote

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生物&药学活性

GNE-140 racemate is the racemate of GNE-140, a novel potent, selective lactate dehydrogenase (LDH) inhibitor with IC50 of 3, 5, and 5 nM for LDHA, LDHB, and LDHC, respectively.
GNE-140 racemate displays no inhibition on malate MDH-1, MDH-2 (IC50>10 uM for both enzymes), and no appreciable inhibition against a panel of 301 kinases (<50% inhibition at 1 uM).
GNE-140 racemate perturbs glycolysis and inhibits proliferation in MIA PaCa-2 cells (IC50=0.43 uM), decreases glucose uptake (IC50=0.47 uM).
Pancreatic cell lines that utilize oxidative OXPHOS rather than glycolysis are inherently resistant to GNE-140, which can be resensitized to GNE-140 with the OXPHOS inhibitor phenformin.

物理化学性质&存储条件

分子量	499.0447
分子式	C25H23ClN2O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 34 mg/mL
Chemical Name/SMILES	2,4-Piperidinedione, 3-[(2-chlorophenyl)thio]-6-[4-(4-morpholinyl)phenyl]-6-(3-thienyl)-

参考文献

1. Boudreau A, et al. Nat Chem Biol. 2016 Oct;12(10):779-86.

GNE-140 racemate (GNE 140 racemate;GNE140 racemate)

生物&药学活性

物理化学性质&存储条件

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GNE-140 racemate (GNE 140 racemate;GNE140 racemate)

生物&药学活性

物理化学性质&存储条件

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