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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-ROR-GNE-0946
GNE-0946

Chemical Structure : GNE-0946

CAS No.: 1677667-24-1

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GNE-0946 (GNE0946)

货号: PC-22403Not For Human Use, Lab Use Only.

GNE-0946 is a potent and selective RORc (RORγ) inverse agonist with cell EC50 of 4 nM, inhibits IL-17 production in hPBMC with EC50 of 17 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GNE-0946 is a potent and selective RORc (RORγ) inverse agonist with cell EC50 of 4 nM, inhibits IL-17 production in hPBMC with EC50 of 17 nM.
GNE-0946 displays >300-fold selectivity for RORc over the other ROR family members, PPARγ, and NRs.

物理化学性质&存储条件

分子量 460.79
分子式 C22H12ClF3N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[3-[2-Chloro-6-(trifluoromethyl)benzoyl]imidazo[1,5-a]pyridin-1-yl]-2-hydroxybenzoic acid

参考文献

1. Benjamin P Fauber, et al. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2907-12.

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