GNE-049 |CAS:1936421-41-8 Probechem Biochemicals

Chemical Structure : GNE-049

CAS No.: 1936421-41-8

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GNE-049 (GNE049;GNE 049)

货号: PC-61641Not For Human Use, Lab Use Only.

GNE-049 (GNE049) is a potent, selective, orally available inhibitor of CBP/p300 bromodomain with biochemical IC50 of 1.1/2.3 nM, respectively.

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5 mg	￥3280	In stock
10 mg	￥5280	In stock
25 mg	￥8580	In stock
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生物&药学活性

GNE-049 (GNE049) is a potent, selective, orally available inhibitor of CBP/p300 bromodomain with biochemical IC50 of 1.1/2.3 nM, respectively.
GNE-049 displays 3,850-fold selectivity over BRD4.
GNE-049 shows excellent potency (12 nM) in a BRET cellular assay and inhibits the expression of MYC with EC50 of 14 nM in MV-4-11 cells.
GNE-049 demonstrates significant dose-dependent inhibition of AR signaling and PC proliferation in vitro and in vivo.

物理化学性质&存储条件

分子量	510.59
分子式	C27H32F2N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one

参考文献

1. Jin L, et al. Cancer Res. 2017 Aug 17. pii: canres.0314.2017.

GNE-049 (GNE049;GNE 049)

生物&药学活性

物理化学性质&存储条件

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GNE-049 (GNE049;GNE 049)

生物&药学活性

物理化学性质&存储条件

参考文献

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