GMFBI.1

Chemical Structure : GMFBI.1

CAS No.: 709608-85-5

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货号: PC-72080Not For Human Use, Lab Use Only.

GMFBI.1 is a small molecule that specifically block Ser83 phosphorylation site on Glia maturation factor-β (GMF-β), directly binds to hGMF-β protein with Kd of 19.9 uM.

规格	价格	库存
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
250 mg		Get quote

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生物&药学活性

GMFBI.1 is a small molecule that specifically block Ser83 phosphorylation site on Glia maturation factor-β (GMF-β), directly binds to hGMF-β protein with Kd of 19.9 uM.
GMFBI.1 inhibits PKA mediated phosphorylation of hGMF-β substrate in vitro and is non-toxic at lower concentrations on astrocyte cultures, significantly suppresses GMF-β phosphorylation on Ser83 at 250ng/mL (1.68uM).
GMFBI.1 reduces p38MAPK phosphorylation and NFκB expression levels in GMF-β overexpressing LPS induced astrocytes in vitro.
GMFBI.1 inhibitor reversed EAE and suppressed the proinflammatory response in severely paralyzed EAE animals.

物理化学性质&存储条件

分子量	148.165
分子式	C8H8N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1H-Indazol-4-yl)methanol

参考文献

1. Jane Jose Vattathara, et al. Sci Rep. 2020 Mar 2;10(1):3790.

GMFBI.1

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GMFBI.1

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