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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-NADPH Oxidase (NOX)-GLX7013114
GLX7013114

Chemical Structure : GLX7013114

CAS No.:

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GLX7013114 (GLX-7013114)

货号: PC-73001Not For Human Use, Lab Use Only.

GLX7013114 (GLX-7013114) is a novel selective NADPH oxidase 4 (Nox4) inhibitor with IC50 of 0.3 uM in in CJ Nox4 HEK 293 cell asays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    GLX7013114 (GLX-7013114) is a novel selective NADPH oxidase 4 (Nox4) inhibitor with IC50 of 0.3 uM in in CJ Nox4 HEK 293 cell asays.
    GLX7013114 displays no activity against Nox 1/2/3/5, as well as Glucose oxidase and Xanthine oxidase; does not display any redox activity.
    GLX7013114 inhibits TGFβ-induced upregulation of mesenchymal genes.
    GLX7013114 protected islet cells against both cytokines and high glucose + palmitate.

    物理化学性质&存储条件

    分子量
    分子式
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 Month
    Shipping
    Solubility

    Chemical Name/SMILES

    参考文献

    1. Wang X, et al. PLoS One. 2018 Sep 28;13(9):e0204271.

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