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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-NADPH Oxidase (NOX)-GLX481372
GLX481372

Chemical Structure : GLX481372

CAS No.: 1990478-58-4

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GLX481372 (GLX 481372, GLX-481372)

货号: PC-73002Not For Human Use, Lab Use Only.

GLX481372 is a potent, selective NADPH oxidase 4 and 5 (Nox4 and Nox5) selective inhibitor with IC50 of 0.68 and 0.57 uM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    GLX481372 is a potent, selective NADPH oxidase 4 and 5 (Nox4 and Nox5) selective inhibitor with IC50 of 0.68 and 0.57 uM, respectively.
    GLX481372 weakly inhibited NOX1 and NOX2 with IC50 of >7 uM.
    GLX481372 reduced human islet ROS production in human islet cells.

    物理化学性质&存储条件

    分子量 403.534
    分子式 C23H29N7
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N2-(3,4-Dimethylphenyl)-6-((4-(p-tolyl)piperazin-1-yl)methyl)-1,3,5-triazine-2,4-diamine

    参考文献

    1. Wang X, et al. PLoS One. 2018 Sep 28;13(9):e0204271.

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