GLX481304 | Nox2/Nox4 inhibitor | Probechem Biochemicals

Chemical Structure : GLX481304

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GLX481304 (GLX 481304)

货号: PC-47046Not For Human Use, Lab Use Only.

GLX481304 is a specific small molecule inhibitor of Nox2 and Nox4 with IC50 values of 1.25 uM, shows negligible effects on Nox1.

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生物&药学活性

GLX481304 is a specific small molecule inhibitor of Nox2 and Nox4 with IC50 values of 1.25 uM, shows negligible effects on Nox1.
GLX481304 inhibits generation of reactive oxygen species in isolated cardiomyocytes.
GLX481304 improves cardiomyocyte contractility after hypoxia-reoxygenation.
GLX481304 improves whole heart contractility after hypoxia-reoxygenation in Langendorff perfused mouse heartsimproves whole heart contractility after hypoxia-reoxygenation in Langendorff perfused mouse hearts.

物理化学性质&存储条件

分子量	419.533
分子式	C23H29N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N2-(3,4-dimethylphenyl)-6-((4-(3-methoxyphenyl)piperazin-1-yl)methyl)-1,3,5-triazine-2,4-diamine

参考文献

1. Ferenc L M Szekeres, et al. Sci Rep. 2021 Jun 7;11(1):11970.

GLX481304 (GLX 481304)

生物&药学活性

物理化学性质&存储条件

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GLX481304 (GLX 481304)

生物&药学活性

物理化学性质&存储条件

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