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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-NADPH Oxidase (NOX)-GLX351322
GLX351322

Chemical Structure : GLX351322

CAS No.: 835598-94-2

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GLX351322 (GLX 351322;GLX-351322)

货号: PC-35364Not For Human Use, Lab Use Only.

GLX351322 (GLX-351322) is a novel potent inhibitor of NADPH oxidase 4 (Nox4), inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 uM.

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10 mg ￥1880 In stock
25 mg ￥3280 In stock
50 mg ￥5280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GLX351322 (GLX-351322) is a novel potent inhibitor of NADPH oxidase 4 (Nox4), inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 uM.
GLX351322 dispplays an order of magnitude less activity against NOX2; counteracts non-fasting hyperglycemia and impairs glucose tolerance in HFD-treated male C57BL/6 mice, prevents high-glucose-induced human islet cell reactive oxygen species (ROS) production and death.

物理化学性质&存储条件

分子量 431.507
分子式 C21H25N3O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Ethyl 2-[[2-[4-(furan-2-carbonyl)piperazin-1-yl]acetyl]amino]-5,6-dihydro-4H-cyclopenta-[b]thiophene-3-carboxylate

参考文献

1. Anvari E, et al. Free Radic Res. 2015;49(11):1308-18.

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