GLUT8 inhibitor P20

Chemical Structure : GLUT8 inhibitor P20

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货号: PC-25531Not For Human Use, Lab Use Only.

GLUT8 inhibitor P20 is a selective inhibitor of glucose transporter GLUT8 (SLC2A8) with IC50 of 2.1 uM, 2.9-fold selective over GLUT2.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

GLUT8 inhibitor P20 is a selective inhibitor of glucose transporter GLUT8 (SLC2A8) with IC50 of 2.1 uM, 2.9-fold selective over GLUT2.
GLUT8 inhibitor P20 is selective for GLUT8 against other class I GLUTs: GLUT1, -3, and -4, as well as the GLUT5 fructose-only transporter
GLUT8 inhibitor P20 also inhibits GLUT8-mediated fructose uptake with IC50 of 2.1 uM.
GLUT8 inhibitor P20 (10 uM) reverses fructose-induced suppression of key fasting-responsive genes in hepatocytes, induces fasting signaling factors fibroblast growth factor 21 (FGF2134,35) and PGC1α.
GLUT8 inhibitor P20 reversed fructose-induced hepatocyte TG accumulation, lowered fructose-induced inflammatory gene markers Il6, Cxcl2, and Tgf-β and glutamine metabolic genes Glul and Slc25a13.

物理化学性质&存储条件

分子量	333.35
分子式	C19H15N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(furan-2-yl)-N-(2-(pyridin-4-yl)benzo[d]oxazol-5-yl)propanamide

参考文献

1. Adams JA, et al. Hepatol Commun. 2025 Sep 22;9(10):e0810.