GLS4 (Morphothiadin) | HBV capsid inhibitor | Probechem Biochemicals

Chemical Structure : GLS4

CAS No.: 1092970-12-1

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GLS4 (GLS 4, Morphothiadin)

货号: PC-63326Not For Human Use, Lab Use Only.

GLS4 (Morphothiadin) is a potent inhibitor of HBV capsid assembly, inhibits HBV replication (EC50=62.24 nM).

规格	价格	库存
2 mg	￥1480	In stock
5 mg	￥2580	In stock
10 mg	￥4280	In stock
25 mg	￥7280	In stock
100 mg		Get quote

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生物&药学活性

GLS4 (Morphothiadin) is a potent inhibitor of HBV capsid assembly, inhibits HBV replication (EC50=62.24 nM).
GLS4 (Morphothiadin) reduces HBV-DNA levels in HepG.2.2.15 cells (IC50=14 nM), shows efficacy against ADV-resistant HBV mutations.
GLS4 (Morphothiadin) strongly inhibits core gene expression (at 100 to 200 nM), suppresses virus accumulation in the supernantant of HepAD38 cells.
GLS4 (Morphothiadin) inhibits HBV replicative forms in the live, shows strong and sustained suppression of virus DNA in treated mice.

物理化学性质&存储条件

分子量	509.394
分子式	C21H22BrFN4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 100 mg/mL
Chemical Name/SMILES	ethyl 4-(2-bromo-4-fluorophenyl)-6-(morpholinomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

参考文献

1. Wang XY, et al. Antivir Ther. 2012;17(5):793-803.

2. Wu G, et al. Antimicrob Agents Chemother. 2013 Nov;57(11):5344-54.

3. Ren Q, et al. Bioorg Med Chem. 2017 Feb 1;25(3):1042-1056.

4. Tu T, et al. J Virol. 2018 Feb 7. pii: JVI.02007-17.

GLS4 (GLS 4, Morphothiadin)

生物&药学活性

物理化学性质&存储条件

参考文献

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GLS4 (GLS 4, Morphothiadin)

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物理化学性质&存储条件

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