GLPG2737 | CFTR corrector | Probechem Biochemicals

Chemical Structure : GLPG2737

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GLPG2737 (GLPG-2737)

货号: PC-26905Not For Human Use, Lab Use Only.

GLPG2737 is a potent type 2 CFTR corrector with EC50 of 71 nM, rescues the trafficking of ΔF508 CFTR to the plasma membrane in epithelial cell line stably expressing ΔF508 CFTR.

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生物&药学活性

GLPG2737 is a potent type 2 CFTR corrector with EC50 of 71 nM, rescues the trafficking of ΔF508 CFTR to the plasma membrane in epithelial cell line stably expressing ΔF508 CFTR.

物理化学性质&存储条件

分子量	613.75
分子式	C30H40FN7O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-cyclobutyl-N-(N,N-dimethylsulfamoyl)-1-(4-fluorophenyl)-4-(4-methoxy-[1,4'-bipiperidin]-1'-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxamide

参考文献

1. Pizzonero M, et al. J Med Chem. 2024 Apr 11;67(7):5216-5232.

2. van Koningsbruggen-Rietschel S, et al. J Cyst Fibros. 2020 Mar;19(2):292-298.

GLPG2737 (GLPG-2737)

生物&药学活性

物理化学性质&存储条件

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GLPG2737 (GLPG-2737)

生物&药学活性

物理化学性质&存储条件

参考文献

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