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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-CFTR-GLPG2451
GLPG2451

Chemical Structure : GLPG2451

CAS No.: 2055015-61-5

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GLPG2451 (GLPG 2451)

货号: PC-49187Not For Human Use, Lab Use Only.

GLPG2451 (GLPG 2451) is a potent potentiator of cystic fibrosis transmembrane conductance regulator (CFTR) with EC50 of 11 nM for F508del CFTR in the YHA assay and EC50 of 18 nM in TECC assay using HBE cells from patients carrying the F508del mutation.

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5 mg ￥2980 In stock
10 mg ￥4880 In stock
25 mg ￥7680 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GLPG2451 (GLPG 2451) is a potent potentiator of cystic fibrosis transmembrane conductance regulator (CFTR) with EC50 of 11 nM for F508del CFTR in the YHA assay and EC50 of 18 nM in TECC assay using HBE cells from patients carrying the F508del mutation.
GLPG2451 improves the gating function of the CFTR channel.

物理化学性质&存储条件

分子量 419.375
分子式 C16H16F3N3O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-3-amino-N-(2-hydroxypropyl)-5-((4-(trifluoromethoxy)phenyl)sulfonyl)picolinamide

参考文献

1. Gees M, et al. Front Pharmacol. 2018 Oct 26;9:1221.

2. Van der Plas SE, et al. J Med Chem. 2021 Jan 14;64(1):343-353.

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