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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-CFTR-GLPG1837
GLPG1837

Chemical Structure : GLPG1837

CAS No.: 1654725-02-6

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GLPG1837 (GLPG-1837, ABBV-974, ABBV974)

货号: PC-60232Not For Human Use, Lab Use Only.

GLPG1837 (ABBV-974) is a potent, orally available CFTR potentiator with EC50 of 3 nM and 339 nM on F508del and G551D CFTR, respectively.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg ￥5280 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GLPG1837 (ABBV-974) is a potent, orally available CFTR potentiator with EC50 of 3 nM and 339 nM on F508del and G551D CFTR, respectively.
GLPG1837 (ABBV-974) shows enhanced efficacy on CFTR mutants harboring Class III mutations compared to Ivacaftor.

物理化学性质&存储条件

分子量 348.421
分子式 C16H20N4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-carbamoyl-5,5,7,7-tetramethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-1H-pyrazole-5-carboxamide

参考文献

1. Van der Plas SE, et al. J Med Chem. 2017 Nov 17. doi: 10.1021/acs.jmedchem.7b01288.

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