GLPG1690 | Autotaxin inhibitor | Probechem Biochemicals

Chemical Structure : GLPG1690

CAS No.: 1628260-79-6

加入收藏

GLPG1690 (Ziritaxestat, GLPG 1690)

货号: PC-60402Not For Human Use, Lab Use Only.

GLPG1690 (Ziritaxestat, GLPG 1690) is a first-in-class, potent, competitive autotaxin inhibitor with Ki/IC50 of 15 nM/131 nM.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

GLPG1690 (Ziritaxestat, GLPG 1690) is a first-in-class, potent, competitive autotaxin inhibitor with Ki/IC50 of 15 nM/131 nM.
GLPG1690 (Ziritaxestat) inhibits ATX-induced LPA 18:2 production in mouse, rat, and healthy donor plasma with IC50 of 418 nM, 542 nM, and 242 nM, respectively.
GLPG1690 (Ziritaxestat shows no CYP3A4 TDI and decreased hERG inhibitory activity (IC50=15 uM), and good pharmacokinetic profile for treatment idiopathic pulmonary fibrosis.
GLPG1690 also is an inhibitor of the ectonucleotide pyrophosphatase/ phosphodiesterase family (ENPP2).

物理化学性质&存储条件

分子量	588.71
分子式	C30H33FN8O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]-piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]-methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile

参考文献

1. Desroy N, et al. J Med Chem. 2017 May 11;60(9):3580-3590.

GLPG1690 (Ziritaxestat, GLPG 1690)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

GLPG1690 (Ziritaxestat, GLPG 1690)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.