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首页-小分子抑制剂&激动剂-GPCR-Free Fatty Acid Receptor (FFAR)-GLPG0974
GLPG0974

Chemical Structure : GLPG0974

CAS No.: 1391076-61-1

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GLPG0974 (GLPG-0974)

货号: PC-62591Not For Human Use, Lab Use Only.

GLPG 0974 is a potent, selective free fatty acid receptor 2 (FFA2, GPR43) antagonist with IC50 of 95 nM.

规格 价格 库存 数量
5 mg ￥1480 In stock
10 mg ￥2380 In stock
25 mg ￥3980 In stock
50 mg ￥5980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GLPG0974 is a potent, selective free fatty acid receptor 2 (FFA2, GPR43) antagonist with IC50 of 95 nM.
GLPG0974 inhibits acetate-induced neutrophil migration strongly in vitro with IC50 of 27 nM.
GLPG0974 demonstrates ability to inhibit a neutrophil-based pharmacodynamic (PD) marker, CD11b activation-specific epitope [AE], in a human whole blood assay.

物理化学性质&存储条件

分子量 484.995
分子式 C25H25ClN2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[[[(2R)-1-(Benzo[b]thien-3-ylcarbonyl)-2-methyl-2-azetidinyl]carbonyl][(3-chlorophenyl)

参考文献

1. Pizzonero M, et al. J Med Chem. 2014 Dec 11;57(23):10044-57.

2. Sergeev E, et al. J Biol Chem. 2016 Jan 1;291(1):303-17.

3. Namour F, et al. Br J Clin Pharmacol. 2016 Jul;82(1):139-48.

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