GLPG0187 | Integrin inhibitor | Probechem Biochemicals

Chemical Structure : GLPG0187

CAS No.: 1320346-97-1

加入收藏

GLPG0187 (GLPG 0187, GLPG-0187)

货号: PC-42179Not For Human Use, Lab Use Only.

GLPG0187 (GLPG 0187) is a highly potent, broad spectrum integrin receptor antagonist with IC50 of 1-10 nM for αvβ1, αvβ3, αvβ5, αvβ6, αvβ8 and α5β1.

规格	价格	库存
5 mg	￥2180	In stock
10 mg	￥3580	In stock
25 mg	￥5580	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

GLPG0187 (GLPG 0187) is a highly potent, broad spectrum integrin receptor antagonist with IC50 of 1-10 nM for αvβ1, αvβ3, αvβ5, αvβ6, αvβ8 and α5β1.
GLPG0187 significantly inhibits angiogenesis both in vivo and in vitro, osteoclastogenesis in vitro, and bone loss in vivo.
GLPG0187 inhibits de novo formation and progression of bone and visceral metastases in prostate cancer and breast cancer mice models.

物理化学性质&存储条件

分子量	595.713
分子式	C29H37N7O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 15 mg/mL
Chemical Name/SMILES	L-Alanine, 3-[[2,5-dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-1-piperidinyl]-4-pyrimidinyl]amino]-N-[(4-methoxyphenyl)sulfonyl]-

参考文献

1. Pujuguet P, et al. Eur J Cancer. 2011;47:S28. doi: 10.1016/S0959-8049(11)72695-8.

2. Cirkel GA, et al. Invest New Drugs. 2016 Apr;34(2):184-92.

3. van der Horst G, et al. Neoplasia. 2011 Jun;13(6):516-25.

4. Reeves KJ, et al. Int J Cancer. 2015 Apr 1;136(7):1731-40.

GLPG0187 (GLPG 0187, GLPG-0187)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

GLPG0187 (GLPG 0187, GLPG-0187)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.