GLPG-2222 |CAS:1918143-53-9 Probechem Biochemicals

Chemical Structure : GLPG-2222

CAS No.: 1918143-53-9

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GLPG-2222 (ABBV-2222;ABBV2222;GLPG2222)

货号: PC-60231Not For Human Use, Lab Use Only.

GLPG-2222 (ABBV-2222, Galicaftor) is a novel potent and efficacious CFTR corrector with EC50 of 5 nM.

规格	价格	库存
2 mg	￥2280	In stock
5 mg	￥4280	In stock
10 mg	￥7280	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

GLPG-2222 (ABBV-2222, Galicaftor) is a novel potent and efficacious CFTR corrector with EC50 of 5 nM.
GLPG-2222 is highly potent (5 nM) and efficacious in cells from multiple CF patient donors that have F508del homozygous mutation.
GLPG-2222 shows potential in clinical trials in patients harboring the F508del CFTR mutation on at least one allele.

物理化学性质&存储条件

分子量	559.47
分子式	C28H21F4NO7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[(2R,4R)-4-({[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic acid

参考文献

1. Wang X, et al. J Med Chem. 2017 Dec 18. doi: 10.1021/acs.jmedchem.7b01339.

GLPG-2222 (ABBV-2222;ABBV2222;GLPG2222)

生物&药学活性

物理化学性质&存储条件

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询单

GLPG-2222 (ABBV-2222;ABBV2222;GLPG2222)

生物&药学活性

物理化学性质&存储条件

参考文献

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