Setanaxib (GKT137831) | NOX1/4 inhibitor | Probechem Biochemicals

Chemical Structure : GKT137831

CAS No.: 1218942-37-0

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GKT137831 (Setanaxib, GKT-137831, GKT831)

货号: PC-42961Not For Human Use, Lab Use Only.

GKT137831 (Setanaxib, GKT-137831) is a potent, selective, dual NADPH oxidase Nox1/4 inhibitor with Ki of 110/140 nM, 15-fold less potent on Nox2 and 3-fold less potent on Nox5, and no affinity for xanthine oxidase.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg	￥5280	In stock
250 mg		Get quote

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生物&药学活性

GKT137831 (Setanaxib, GKT-137831) is a potent, selective, dual NADPH oxidase Nox1/4 inhibitor with Ki of 110/140 nM, 15-fold less potent on Nox2 and 3-fold less potent on Nox5, and no affinity for xanthine oxidase.
GKT137831 (Setanaxib) attenuates liver fibrosis and ROS production in both SOD1mu and WT mice, suppresses ROS production and NOX and fibrotic gene expression, but not Rac1 activity, in SOD1mut and WT in hepatic stellate cells (HSCs).

物理化学性质&存储条件

分子量	394.8542
分子式	C21H19ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 37 mg/mL
Chemical Name/SMILES	1H-Pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione, 2-(2-chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-

参考文献

1. Jiang JX, et al. Free Radic Biol Med. 2012 Jul 15;53(2):289-96.

2. Aoyama T, et al. Hepatology. 2012 Dec;56(6):2316-27.

3. Gray SP, et al. Circulation. 2013 May 7;127(18):1888-902.

4. Laleu B, et al. J Med Chem. 2010 Nov 11;53(21):7715-30.

GKT137831 (Setanaxib, GKT-137831, GKT831)

生物&药学活性

物理化学性质&存储条件

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GKT137831 (Setanaxib, GKT-137831, GKT831)

生物&药学活性

物理化学性质&存储条件

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