GKI-1 | MASTL inhibitor | Probechem Biochemicals

Chemical Structure : GKI-1

CAS No.: 2444764-03-6

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GKI-1 (Greatwall Kinase Inhibitor-1)

货号: PC-20557Not For Human Use, Lab Use Only.

GKI-1 (Greatwall Kinase Inhibitor-1) is a specific small-molecule inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, Greatwall/GWL) with IC50 of 10.2 uM.

规格	价格	库存
5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

GKI-1 (Greatwall Kinase Inhibitor-1) is a specific small-molecule inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, Greatwall/GWL) with IC50 of 10.2 uM.
GKI-1 inhibits hGWLFL and hGWL-KinDom with IC50 of 4.9 and 2.5 μM respectively.
GKI-1 displays 2-fold selectivity for binding to hGWLFL over ROCK1, and > 8-fold selectivity over PKA.
GKI-1 reduces ENSA/ARPP19 phosphorylation levels in HeLa cells, resulting in a decrease in mitotic events, mitotic arrest/cell death and cytokinesis failure, which is comparable to siRNA depletion of GWL.

物理化学性质&存储条件

分子量	269.73
分子式	C15H12ClN3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-chlorophenyl)-3-(1H-pyrazol-4-yl)aniline

参考文献

1. Ocasio CA, et al. Oncotarget. 2016 Nov 1;7(44):71182-71197.

2. Kim AY, et al. Front Oncol. 2020 Sep 29;10:571601.

GKI-1 (Greatwall Kinase Inhibitor-1)

生物&药学活性

物理化学性质&存储条件

参考文献

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GKI-1 (Greatwall Kinase Inhibitor-1)

生物&药学活性

物理化学性质&存储条件

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