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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Autotaxin-GK442
GK442

Chemical Structure : GK442

CAS No.: 2047917-85-9

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GK442 (GK-442)

货号: PC-23707Not For Human Use, Lab Use Only.

GK442 is a highly potent autotaxin inhibitor with IC50 of 60 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GK442 is a highly potent autotaxin inhibitor with IC50 of 60 nM.
GK442 (30 mg/kg, i.p.) exhibited promising efficacy in a mouse model of pulmonary inflammation and fibrosis induced by bleomycin.

物理化学性质&存储条件

分子量 391.51
分子式 C21H33N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N1-(1-(Hydroxyamino)-1-oxononan-5-yl)-N6-phenyladipamide

参考文献

1. Nikolaou A, et al. J Med Chem. 2018 Apr 26;61(8):3697-3711.

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