GK13S | UCHL1 inhibitor | Probechem Biochemicals

Chemical Structure : GK13S

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GK13S (UCHL1 inhibitor GK13S)

货号: PC-49371Not For Human Use, Lab Use Only.

GK13S is a highly potent, specific and covalent inhibitor of deubiquitinase UCHL1 with IC50 of 87 nM, displays exquisite specificity for UCHL1 over the other UCH family members (IC50>10 uM).

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10 mg	￥4580	In stock
25 mg	￥7580	In stock
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生物&药学活性

GK13S is a highly potent, specific and covalent inhibitor of deubiquitinase UCHL1 with IC50 of 87 nM, displays exquisite specificity for UCHL1 over the other UCH family members (IC50>10 uM).
GK13S inhibits recombinant UCHL1 (0.8 uM) with IC50 of 50 nM in a Ubiquitin rhodamine cleavage assay.
Inhibition of UCHL1 by GK13S does not impair cell growth in HEK293 cells.
GK13S reduces monoubiquitin in U-87 MG cells and thereby phenocopies the effect of a UCHL1 mutant mouse.
GK13S is bound covalently to the catalytic cysteine Cys90 through an isothiourea with its cyanamide warhead and occupies a shallow cleft that, during catalysis, guides the Ubiquitin C-terminal LRGG peptide to the active site.

物理化学性质&存储条件

分子量	390.447
分子式	C21H22N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-cyano-N-(1-(4-(pent-4-yn-1-ylcarbamoyl)phenyl)-1H-imidazol-4-yl)pyrrolidine-3-carboxamide

参考文献

1. Grethe C, et al. Nat Commun. 2022 Oct 10;13(1):5950.

GK13S (UCHL1 inhibitor GK13S)

生物&药学活性

物理化学性质&存储条件

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GK13S (UCHL1 inhibitor GK13S)

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物理化学性质&存储条件

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