GJ103 sodium salt | Read-through compound | Probechem Biochemicals

Chemical Structure : GJ103 sodium salt

CAS No.: 1459687-96-7

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GJ103 sodium salt (GJ 103 sodium salt, GJ-103 sodium salt)

货号: PC-42333Not For Human Use, Lab Use Only.

GJ103 sodium salt is a novel small molecular read-through (SMRT) compound that can induce read through of nonsense mutations in the ATM gene.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

GJ103 sodium salt is a novel small molecular read-through (SMRT) compound that can induce read through of nonsense mutations in the ATM gene.
GJ103 sodium salt induces ATM kinase on both TGA and TAG stop codons and restores ATMpSer1981 autophosphorylation and SMC1pSer966 transphosphorylation in A-T cells.

物理化学性质&存储条件

分子量	364.35418928
分子式	C16H13N4NaO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 34 mg/mL
Chemical Name/SMILES	Acetic acid, 2-[[4-(3-methoxyphenyl)-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-, sodium salt (1:1)

参考文献

1. Du L, et al. Mol Ther. 2013 Sep;21(9):1653-60.

GJ103 sodium salt (GJ 103 sodium salt, GJ-103 sodium salt)

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物理化学性质&存储条件

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询单

GJ103 sodium salt (GJ 103 sodium salt, GJ-103 sodium salt)

生物&药学活性

物理化学性质&存储条件

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