GIV3727 |CAS:957136-80-0 Probechem Biochemicals

Chemical Structure : GIV3727

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GIV3727 (GIV 3727;GIV-3727)

货号: PC-61223Not For Human Use, Lab Use Only.

GIV3727 is a novel potent bitter receptor (TAS2Rs) antagonist that inhibits activation of hTAS2R31 by saccharin and acesulfame K with IC50 of 6.4 and 7.9 uM respectively.

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生物&药学活性

GIV3727 is a novel potent bitter receptor (TAS2Rs) antagonist that inhibits activation of hTAS2R31 by saccharin and acesulfame K with IC50 of 6.4 and 7.9 uM respectively.
GIV3727 also similarly inhibits hTAS2R43 activated by saccharin and acesulfame K, and inhibits multiple hTAS2Rs (19/25), including hTAS2R31 and 43.
GIV3727 decreases bitter taste intensity in humans, specifically affects only bitter taste perception.
GIV3727 is a useful chemical probe to examine the precise contributions of bitter receptor signaling in non-gustatory systems.

物理化学性质&存储条件

分子量	198.306
分子式	C12H22O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2,2,3-trimethylcyclopentyl)butanoic acid

参考文献

1. Slack JP, et al. Curr Biol. 2010 Jun 22;20(12):1104-9.

GIV3727 (GIV 3727;GIV-3727)

生物&药学活性

物理化学性质&存储条件

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GIV3727 (GIV 3727;GIV-3727)

生物&药学活性

物理化学性质&存储条件

参考文献

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