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首页-小分子抑制剂&激动剂-Others-Other Targets-GIT1/β-Pix inhibitor 14-5-18
GIT1/β-Pix inhibitor 14-5-18

Chemical Structure : GIT1/β-Pix inhibitor 14-5-18

CAS No.: 2070916-70-8

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GIT1/β-Pix inhibitor 14-5-18

货号: PC-26308Not For Human Use, Lab Use Only.

GIT1/β-Pix inhibitor 14-5-18 is a small-molecule inhibitor to interrupt the protein–protein interaction (PPI) of GIT1/β-Pix complex with Ki of 1.8 uM in FP assays, directly binds to GIT1 with BLI KD of 7.7 uM, inhibits gastric cancer metastasis.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GIT1/β-Pix inhibitor 14-5-18 is a small-molecule inhibitor to interrupt the protein–protein interaction (PPI) of GIT1/β-Pix complex with Ki of 1.8 uM in FP assays, directly binds to GIT1 with BLI KD of 7.7 uM, inhibits gastric cancer metastasis.

物理化学性质&存储条件

分子量 391.42
分子式 C23H21NO5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl (1S,2R,3R,4S,E)-6-(furan-3-ylmethylene)-1'-methyl-2',5-dioxospiro[bicyclo[2.2.1]heptane-2,3'-indoline]-3-carboxylate

参考文献

1. Jing Gu, et al. Nat Commun. 2022 Nov 23;13(1):7176.

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