欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Matrix Metalloproteinase (MMP)-GI254023X
GI254023X

Chemical Structure : GI254023X

CAS No.: 260264-93-5

加入收藏

GI254023X (GI 254023X, GI4023, SRI028594)

货号: PC-73195Not For Human Use, Lab Use Only.

GI 254023X (GI4023, SRI028594) is a potent, preferential ADAM10 inhibitor with IC50 of 5.3 nM, also inhibits MMP9 (IC50=2.5 nM), preferentially blocking ADAM10 but not TACE.

规格 价格 库存 数量
1 mg ￥980 In stock
5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥4280 In stock
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GI 254023X (GI4023, SRI028594) is a potent, preferential ADAM10 inhibitor with IC50 of 5.3 nM, also inhibits MMP9 (IC50=2.5 nM), preferentially blocking ADAM10 but not TACE.
GI 254023X displays >100-fold selectivity for ADAM10 over ADAM17 (TACE).
GI 254023X bolcks antibody-induced shedding of target antigens, increases specificity of targeted immunotherapy in vitro.
GI 254023X inhibits PACAP-induced shedding of RAGE in PAC1/RAGE cells.
GI 254023X remarkably inhibits the proliferation and induce the apoptosis of H929 cells.

物理化学性质&存储条件

分子量 391.51
分子式 C21H33N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-N-((S)-3,3-Dimethyl-1-(methylamino)-1-oxobutan-2-yl)-2-((S)-1-(N-hydroxyformamido)ethyl)-5-phenylpentanamide

参考文献

1. Hundhausen C, et al. Blood. 2003 Aug 15;102(4):1186-95.

2. Budagian V, et al. J Biol Chem. 2004 Sep 24;279(39):40368-75.

3. Verena V Metz, et al. PLoS One.2012;7(7):e41823.

4. Eichenauer DA, et al. Cancer Res. 2007 Jan 1;67(1):332-8.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: