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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Other Viruses-GHP-88310
GHP-88310

Chemical Structure : GHP-88310

CAS No.: 3135761-29-1

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GHP-88310 (EIDD-3608, GHP88310)

货号: PC-27376Not For Human Use, Lab Use Only.

GHP-88310 (EIDD-3608) is an orally efficacious, non-nucleoside, broad-spectrum orthoparamyxovirus RNA-dependent RNA polymerase (RdRP) inhibitor, shows broad-spectrum antiviral activities for HPIV3, Sendai virus (SeV), MeV, and related canine distemper virus (CDV) with EC50 of 0.53 uM, 1.03 uM and 1.71 uM respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GHP-88310 (EIDD-3608) is an orally efficacious, non-nucleoside, broad-spectrum orthoparamyxovirus RNA-dependent RNA polymerase (RdRP) inhibitor, shows broad-spectrum antiviral activities for HPIV3, Sendai virus (SeV), MeV, and related canine distemper virus (CDV) with EC50 of 0.53 uM, 1.03 uM and 1.71 uM respectively.
GHP-88310 shows submicromolar activity against orthoparamyxoviruses of the respirovirus [HPIV1, HPIV3, and Sendai virus (SeV)], morbillivirus [MeV and canine distemper virus (CDV)], and henipavirus (Ghana henipavirus and Cedar virus) genera.
GHP-88310 prevents initiation of the viral RdRP complex at the promoter, most likely by sterically blocking structural reorganization of the polymerase from initiation into elongation configuration.
GHP-88310 lowers the respiratory tract viral load in HPIV3-infected cotton rats.
GHP-88310 causes complete survival, reduction of viremia and shed viral load, and alleviated lymphocytopenia in ferrets infected with CDV.
GHP-88310 blocks contact-mediated and airborne transmission in a ferret model of measles-like disease/

物理化学性质&存储条件

分子量 278.32
分子式 C16H14N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(methylamino)-6-(2,7-naphthyridin-4-yl)benzamide

参考文献

1. Lieber CM, et al. Sci Adv. 2026 May 22;12(21):eaef1594.

2. Lieber CM, et al. Nat Microbiol. 2026 Jul 24. doi: 10.1038/s41564-026-02419-y.

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