GHP-88309 | Paramyxovirus inhibitor | Probechem Biochemicals

Chemical Structure : GHP-88309

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GHP-88309 (GHP88309)

货号: PC-73390Not For Human Use, Lab Use Only.

GHP-88309 (GHP88309) is a non-nucleoside, broad-spectrum allosteric inhibitor of paramyxovirus polymerase with EC50 of 0.9 uM against HPIV3-JS RdRP.

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生物&药学活性

GHP-88309 (GHP88309) is a non-nucleoside, broad-spectrum allosteric inhibitor of paramyxovirus polymerase with EC50 of 0.9 uM against HPIV3-JS RdRP.
Demonstrates highly potent antiviral potency against HPIV3-JS and clinical isolates HPIV3-9R4 and HPIV3-10L3 in the primary cell/virus isolate system (EC50=0.07-0.08 uM), without cytotoxicity.
GHP-88309 targets a conserved microdomain in the L protein, inhibiting de novo RNA synthesis.
GHP-88309 is efficacious in well-differentiated human airway epithelium cultures grown at air-liquid interface (3D-ALI-HBTEC).
GHP-88309 (150 mg/kg b.i.d.) is orally efficacious in HPIV disease surrogate model.
GHP-88309 possesses unusual broad-spectrum activity against diverse paramyxoviruses including respiroviruses (i.e. HPIV1 and HPIV3) and morbilliviruses (i.e. MeV).

物理化学性质&存储条件

分子量	266.275
分子式	C16H11FN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-fluoro-6-(isoquinolin-5-yl)benzamide

参考文献

1. Robert M Cox, et al. Nat Microbiol. 2020 Oct;5(10):1232-1246.

GHP-88309 (GHP88309)

生物&药学活性

物理化学性质&存储条件

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GHP-88309 (GHP88309)

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