GGTI-2418 | GGTase I inhibitor | Probechem Biochemicals

Chemical Structure : GGTI-2418

CAS No.: 501010-06-6

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GGTI-2418 (GGTI 2418, PTX 100)

货号: PC-62152Not For Human Use, Lab Use Only.

GGTI-2418 (GGTI 2418, PTX 100) is a highly potent, competitive, and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI) with IC50 of 9.5 nM, displays 5,600-fold selectivity over FTase.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GGTI-2418 (GGTI 2418, PTX 100) is a highly potent, competitive, and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI) with IC50 of 9.5 nM, displays 5,600-fold selectivity over FTase.
GGTI 2418 demonstrates competitive inhibition of GGTase I against the H-Ras-CVLL protein with a Ki of 4.4 nM.
GGTI 2418 suppresses the growth of human breast tumors in nude mouse xenografts.
GGTI 2418 increases p27(Kip1) and induces significant regression of breast tumors.

物理化学性质&存储条件

分子量	441.532
分子式	C23H31N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-((S)-2-benzyl-4-((4-methyl-1H-imidazol-5-yl)methyl)-3-oxopiperazine-1-carboxamido)-4-methylpentanoic acid

参考文献

1. Kuchay S, et al. Nature. 2017 Jun 22;546(7659):554-558.

2. Kazi A, et al. Mol Cell Biol. 2009 Apr;29(8):2254-63.

GGTI-2418 (GGTI 2418, PTX 100)

生物&药学活性

物理化学性质&存储条件

参考文献

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GGTI-2418 (GGTI 2418, PTX 100)

生物&药学活性

物理化学性质&存储条件

参考文献

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