GGTI-2417 |CAS:501010-05-5 Probechem Biochemicals

Chemical Structure : GGTI-2417

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GGTI-2417 (GGTI2417)

货号: PC-62151Not For Human Use, Lab Use Only.

GGTI-2417 is the methyl ester prodrug of GGTI-2418, a highly potent, competitive, and selective inhibitor of GGTase I.

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生物&药学活性

GGTI-2417 is the methyl ester prodrug of GGTI-2418, a highly potent, competitive, and selective inhibitor of GGTase I.
GGTI 2417 exhibits potent inhibitory activity against Rap1 geranylgeranylation with IC50 of 400 nM.
GGTI 2417 increases p27 protein levels and induces accumulation in the G0/G1 phase as well as apoptotic cell death in breast cancer cells, and prevents the degradation of nuclear p27.

物理化学性质&存储条件

分子量	455.559
分子式	C24H33N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Leucine, N-[[(2S)-4-[(5-methyl-1H-imidazol-4-yl)methyl]-3-oxo-2-(phenylmethyl)-1-piperazinyl]carbonyl]-, methyl ester (9CI)

参考文献

1. Kuchay S, et al. Nature. 2017 Jun 22;546(7659):554-558.

2. Kazi A, et al. Mol Cell Biol. 2009 Apr;29(8):2254-63.

3. Falsetti SC, et al. Mol Cell Biol. 2007 Nov;27(22):8003-14.

GGTI-2417 (GGTI2417)

生物&药学活性

物理化学性质&存储条件

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GGTI-2417 (GGTI2417)

生物&药学活性

物理化学性质&存储条件

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