GGTI-2154 | GGTase I inhibitor | Probechem Biochemicals

Chemical Structure : GGTI-2154

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GGTI-2154 (GGTI 2154)

货号: PC-22627Not For Human Use, Lab Use Only.

GGTI-2154 is a potent, selective inhibitor geranylgeranyltransferase I (GGTase I) with IC50 f 21 nM, >250-fold selective over FTase.

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生物&药学活性

GGTI-2154 is a potent, selective inhibitor geranylgeranyltransferase I (GGTase I) with IC50 f 21 nM, >250-fold selective over FTase.
GGTI-2154 inhibits the processing of the geranylgeranylated proteins RhoA, Rap1, and R-Ras, but not the farnesylated proteins H-Ras and HDJ-2, in tumors obtained from mice.
GGTI-2154 suppresses constitutively activated phospho-Erk1/2 and phospho-Akt, induce apoptosis, and induce differentiation toward ductolobular breast epithelium.

物理化学性质&存储条件

分子量	420.51
分子式	C24H28N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Leucine, N-[[5-[(1H-imidazol-5-ylmethyl)amino]-2′-methyl[1,1′-biphenyl]-2-yl]carbonyl]-

参考文献

1. Sun J, et al. Cancer Res. 1999 Oct 1;59(19):4919-26.

2. Sun J, et al. Cancer Res. 2003 Dec 15;63(24):8922-9.

GGTI-2154 (GGTI 2154)

生物&药学活性

物理化学性质&存储条件

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GGTI-2154 (GGTI 2154)

生物&药学活性

物理化学性质&存储条件

参考文献

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